Codeine and promethazine is a mix drugs employed to take care of chilly or allergy indicators for instance runny nose, sneezing, and cough.

However it helps A lot of people, this medication incorporates a hazard for abuse and could occasionally lead to dependancy. This risk may very well be larger For those who have a substance use ailment (which include overuse of or addiction to prescription drugs/alcohol).

The concomitant utilization of anticholinergic medications with Promethazine with Codeine Oral Option may well maximize threat of urinary retention and/or significant constipation, which may produce paralytic ileus [seeWARNINGS AND Safety measures (five.

Use promethazine and codeine as purchased by your doctor. Go through all details given for you. Adhere to all instructions intently. Consider with or without food. Get with foods if it results in an upset stomach.

Often use an exact milliliter measuring system when administering Promethazine with Codeine Oral Remedy to make sure that the dose is calculated and administered accurately. A house teaspoon is not an correct measuring product and could lead to overdosage [see Warnings and Safeguards ( 5.seven)]. For prescriptions where a measuring unit is not really presented, a pharmacist can offer an ideal measuring system and can provide Directions for measuring the correct dose. Usually do not overfill.

Utilize other supportive measures (which includes oxygen and vasopressors) within the administration of circulatory shock and pulmonary edema as indicated. Cardiac arrest or arrhythmias would require Highly developed life-support methods. Gastric emptying can be useful in eliminating unabsorbed drug.

Endocrine/Metabolic: Situations of serotonin syndrome, a potentially lifetime-threatening situation, are documented during concomitant utilization of opioids with serotonergic prescription drugs.

The specific mechanism of motion of codeine together with other opiates is not identified; on the other hand, codeine is believed to act centrally over the cough center. In too much doses, codeine will depress respiration.

If you more info employ opioid medicine if you are pregnant, your baby could develop into dependent on the drug. This can cause lifetime-threatening withdrawal signs in the baby immediately after it really is born. Toddlers born dependent on opioids might require health-related procedure for a number of months.

Use with warning in individuals with underlying intestinal motility Issues. The codeine in Promethazine with Codeine Oral Remedy may induce spasm with the sphincter of Oddi, leading to an increase in biliary tract tension. Opioids may well result in increases in serum amylase [seeWARNINGS AND Safeguards (5.21)]. Watch individuals with biliary tract sickness, like acute pancreatitis for worsening signs. Administration of promethazine has been linked with reported cholestatic jaundice.

Promethazine with Codeine Oral Resolution really should be applied with caution in patients with bone-marrow despair. Leukopenia and agranulocytosis are claimed, normally when promethazine has actually been Utilized in association with other known marrow-harmful agents.

Codeine has reduced plasma protein binding with about seven to 25% of codeine sure to plasma proteins. Codeine passes the blood brain barrier as well as placental barrier. Tiny quantities of codeine and its metabolite, morphine, are transferred to human breast milk.

Codeine was not mutagenic in the in vitro bacterial reverse mutation assay or clastogenic within the in vitro Chinese hamster ovary (CHO) mobile chromosomal aberration assay.

are Expecting or approach to be pregnant. PROMETHAZINE WITH CODEINE ORAL Remedy can harm your unborn infant. See “What is the most important information I should understand about PROMETHAZINE WITH CODEINE ORAL Option?” are breastfeeding or decide to breastfeed. Codeine passes into your breast milk and could cause severe Unwanted side effects inside your toddler together with enhanced sleepiness, breathing problems (respiratory depression), and Dying. It is far from regarded if promethazine can pass into your breast milk.